Efthymios Motakis
PhD in Statistics
Senior Research Fellow
Email: mefthymios@gis.a-star.edu.sg, mdcefmo@nus.edu.sg
I am a Senior Research Fellow in the Cardiovascular Research Institute of the National University of Singapore. I am mainly working on single-cell transcriptomics of cardiac regeneration and reprogramming, the dynamics and characterisation of cardiac cell populations and the prediction of heart failure biomarkers with plasma proteomics. On these pages you will find information about my research and professional activities.
Education
Ph.D. in Statistics, School of Mathematics, Faculty of Science, University of Bristol, United Kingdom.
Selected publications
- Motakis E. and Low H.P.D. (2019). ''CONFESS: Fluorescence-based single-cell ordering in R''. Journal of Statistical Software (to appear).
- Kouno T., Moody J., Kwon A.T., Shibayama Y., Kato S., Huang Y., Böttcher M., Motakis E., Mendez M., Severin J., Luginbühl J., Abugessaisa I., Hasegawa A., Takizawa S., Arakawa T., Furuno M., Ramalingam N., West J., Suzuki H., Kasukawa T., Lassmann T., Hon C.C., Arner E., Carninci P., Plessy C., Shin J.W. (2019). ''C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution''. Nature Communications, 10(1):360.
- Grinchuk O.V., Motakis E., Yenamandra S.P., Ow G.S., Jenjaroenpun P., Tang Z., Yarmishyn A.A., Ivshina A.V., Kuznetsov V.A. (2015). ''Sense-antisense gene-pairs in breast cancer and associated pathological pathways''. Oncotarget, 6(39):42197-221.
- Motakis E., Guhl S., Ishizu Y., Itoh M., Kawaji H., de Hoon M., Lassmann T., Carninci P., Hayashizaki Y., Zuberbier T., Forrest A.R.R., Babina M. and the FANTOM consortium (2014). ''Redefinition of the human mast cell transcriptome by deep-CAGE sequencing''. Blood, 123(17):e58-67.
- Low D.H.P. and Motakis E. (2013). ''deltaGseg: Macrostate estimation via molecular dynamics simulations and multiscale time series analysis''. Bioinformatics, 29(19), 2501-2502.
- Motakis E., Nason G.P., Fryzlewicz P., Rutter G.A. (2006). ''Variance stabilization and normalization for one-color microarray data using a data-driven multiscale approach''. Bioinformatics, 22(20), 2547-2553.
Ongoing projects
- (project with S. Ho)
- (project with I. Morres)
- (cell cycle cardiomyocytes with V. Dang)
- Identification of biomarkers in patients with heart failure after acute myocardial infarction using plasma proteomics (with M. Chan and S. Hwee)
- Characterisation of non-myocyte cell populations in the left ventricle of healthy and infarcted mouse hearts (with M. Ackers-Johnson)
- Reprogramming of mouse fibroblasts into cardiomyocytes: transcriptomic analysis and transdifferentiation dynamics at the single-cell level (with C.K. Lim)
Other information
I am currently supervising the computational data analysis of Ms Sharmelee Selvaraji
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